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In a 1999 survey of Floridians, for example, 82 percent supported legal abortion in the case of birth defects, compared with about 40percentt in situations where the woman simply could not afford to raise another child.
This sample size was estimated to be sufficient to rule out a 2.2-fold increase in birth defects compared with the MACDP rate of 2.78 20 21 with 80% power (assuming a 5% level of significance).
Furthermore, after adjusting for maternal demographic variables, we found that women in the high-risk cluster were nearly 31 times more likely to have offspring with birth defects compared with the low-risk cluster.
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Results Among 36 772 infants exposed to any SSRI in early pregnancy, 3.7% (n=1357) had a birth defect compared with 3.1% of 2 266 875 unexposed infants, yielding a covariate adjusted odds ratio of 1.13 (95% confidence interval 1.06 to 1.20).
Among the 36 772 infants exposed to SSRIs or venlafaxine during the first trimester, 1357 (3.7%) had a diagnosis of a major birth defect compared with 713743.23.2%) of the 2 266 875 unexposed infants (adjusted odds ratio 1.13, 95% confidence interval 1.06 to 1.20, fig 1).
Similarly, it was concluded that initiating ART with efavirenz instead of nevirapine induces a smaller potential number of birth defects compared to women with no efavirenz-containing regimens.
We demonstrated that treatment with LdT or LAM did not increase fetus and infant complications or birth defects, compared to infants in the untreated group.
However, low birth weight children had a higher risk of presenting with hypoplastic defects compared with their normal birth weight counterparts.
Risk of birth defects was compared with that reported by the MACDP.
Interestingly, neonates who were in the first trimester on the day of the earthquake displayed a statistically significantly higher birth-defect ratio when compared with other post-earthquake groups.
One general region of interest would be Middle East countries, many of which meet all of those specifications, in addition to having much higher rates of birth defects than Europe, North America and Australia (69.9/1,000 compared with 52.1/1,000 live births) [ 3].
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