Birth asphyxia increased from 37.65 to 47.46% in the first 5 years of the study period except in the year 2005, and it thereafter declined to 11.43% in 2010.
Signs of maternal infection as indicated by PROM, combined with intrapartum asphyxia, increased the risk of an early neonatal death relative to intrapartum asphyxia alone (adjusted odds ratio (AOR) 1.28, 95% CI 1.03 – 1.03).
In analyses stratified by preterm and term births, maternal BMI was related to risks of infant mortality primarily in term births (≥37 weeks), where risks of deaths due to birth asphyxia and other neonatal morbidities increased with maternal overweight and obesity.
Risks of infant deaths due to birth asphyxia and other neonatal morbidities increased with maternal overweight and obesity (table 3).
Furthermore, Okazaki et al. reported the serum HMGB1 level of infants with birth asphyxia to be significantly increased [ 14].
Regarding specific causes of newborn deaths, the commonest cause was severe birth asphyxia associated with severe obstructed labor for 120 newborns (19.2%).
These trials evaluated melatonin as an antioxidant treatment in newborns with birth asphyxia and other conditions associated with increased oxidative stress.
Other major direct causes are preterm delivery and birth asphyxia, with low birth weight and hypothermia representing important contributing factors in many deaths [ 4- 6].
In contrast, in 57 5-year-old children who were at risk for CVI due to pre-maturity or birth asphyxia, a significant increase in the frequency of impairment was seen on six L94 tasks (range 12 38%).
As many as two-thirds of the 3 – 6% of newborns who are born with birth asphyxia could be saved with interventions at birth, including clearing of the airway, tactile stimulation, and assisted ventilation with a bag-and-mask device.
