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Offspring of bipolar subjects were found more vulnerable to develop thyroid antibodies independently from the vulnerability to develop psychiatric disorders.
REM density is increased in euthymic bipolar subjects compared to normal controls (Talbot et al. 2009) suggesting a greater need in bipolar patients.
We used functional magnetic resonance imaging (fMRI) to study manic bipolar subjects as they performed a cognitive task designed to examine the ventrolateral prefrontal emotional arousal network.
A discontinuous style of adaptation to the conflict situation was more marked in the group of remitted bipolar subjects compared with the group with autoimmune thyroiditis, and more marked among the latter than among non-clinical controls.
Bipolar subjects (n = 36) and their non-bipolar co-twins (n = 27) showed an increased prevalence compared with controls (n = 58) (27.7 resp. 25.9 resp. 13.8%), but differences did not reach statistical significance (p = .20) (Table 1).
To examine the implications of cortical changes to the neurocognitive performance in the psychosis and bipolar subjects, a trained research psychologist administered standardised tests as part of a broader battery (described previously) (Hermens et al. 2010a, b, 2011).
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Whether a bipolar subject had experienced positive psychosis had no effect on his/her schizotypy score.
One bipolar subject completed the SCIP at all three sessions but refused to complete some of the baseline NPS tests.
The study included 1,099 affected bipolar research subjects and 1,152 normal comparison subjects that were sampled in 2 cohorts.
The expression levels of eight proteins were found to be significantly elevated and those of the other 17 proteins were significantly lower in bipolar II subjects compared with MDD subjects.
The most significantly enriched (A) cellular component and (B) biological process according to DAVID Bioinformatics Resources based on the 25 differentially expressed proteins identified in bipolar II subjects relative to MDD subjects.
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