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However, utilizing NMR, a recent report observed a highly bipolar organization of the human ASC and ASC2 PYRIN domains [36], [37], revealing that they resemble the molecular surface properties of CARD domains.
The NJ tree based on the 241 markers clearly showed a bipolar organization.
The Structure analysis confirmed the bipolar organization, with K = 2 as the most likely subgroup number.
The most striking particularity of these cells was the bipolar organization of their dendritic tree (equipolarity = 0.18 ± 0.25, see the wedge diagram in Fig. 3 B 3).
Structure-function analysis of the Drosophila melanogaster Kinesin-5, KLP61F, identified a central bipolar assembly (BASS) domain within the coiled-coil rod that is critical for this motor's bipolar organization and whose deletion results in disassembled, mostly monomeric, Kinesin-5 (Acar et al., 2013).
The bipolar organization of Kinesin-5 resembles that of the bipolar class 2 myosin filament that drives the sliding filament mechanism of muscle contraction, cytokinesis and other forms of motility in non-muscle cells (Huxley, 1963; Turbedsky et al., 2005; Billington et al., 2013).
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We conclude that MK2 is involved in maintaining bipolar microtubule organization while microtubule disassembly does not affect MK2 function on chromosomes.
Taken together, these data indicate that Tim is required, directly or indirectly, for multiple mitotic events, including chromosome condensation, sister chromatid cohesion, bipolar microtubule organization, and microtubule assembly on condensed chromatin.
Chromosome segregation during mitosis depends upon Kinesin-5 motors, which display a conserved, bipolar homotetrameric organization consisting of two motor dimers at opposite ends of a central rod.
We argue that engineering resilience, adaptation, and coping are processes that are subsumed within the broader systemic organization of bipolar disorder that ecological resilience characterizes, and that these different definitions of resilience are therefore not mutually exclusive.
Both appear to be involved, but do not seem to be mediating the fast inhibitory feedback system that underlies the center/surround organization of bipolar cells.
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