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The electron current is more crucial than hole current to determine the efficiency in the bipolar light-emitting diode.
The small and statistically insignificant DC shift is not surprising given the small size of OFF bipolar cell light responses which averaged, under these highly light-adapted conditions, only 14.9±3.38 pA.
Consistent with this hypothesis, the SOCE antagonist MRS 1845 partially reduced the amplitude of the horizontal and OFF bipolar cell light response while having less effect on the fast initial EPSC component (mediated by L-type channels).
The reduction in OFF bipolar cell light-evoked currents was not significantly less than the reduction in HC light-evoked currents (P = 0.1, unpaired t-test).
The reduction in OFF bipolar cell light-evoked currents was not significantly different from the reduction in horizontal cell light-evoked currents.
In particular, a therapeutic strategy under investigation for advanced forms of blindness involves using optogenetic molecules to render ON-bipolar cells light-sensitive.
Even with a supportive partner I sometimes need Twitter as a place to say the unsayable and bring the very dark side of bipolar into the light.
Recording the nerve impulses produced by the bipolar cells as light shone on the retina revealed that RGS depletion affects these neurons in three ways: how sensitive they are to the signals sent by the rod and cone cells, how quickly they respond to a signal, and the size of the electrical response that they produce.
New clues to how lithium soothes the bipolar brain may shed light on other mental illnesses.
This type of bipolar invariably comes to light after some famous person has behaved badly.
The TRPM1 null mutant mouse completely loses the ON bipolar cell photoresponses to light, indicating that TRPM1 plays a critical role in the synaptic transmission from photoreceptors to ON-bipolar cells [13], [15].
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