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Indeed, meta-analysis of bipartite interactions found that mutualistic webs are more specialized than antagonistic ones [ 1].
The computational network-based TDB scoring system is able to assess, in probabilistic terms, the likelihood of reactions in metabolic reconstructions solely on the basis of the structure of the bipartite interactions between metabolites and reactions.
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Taken together, these two papers open up a stunning new vista of GPCR arrestin interactions in which an essential, bipartite interaction occurs through the receptor's core and phosphorylated C terminus (Fig. 1a).
Nestedness is a statistical property of bipartite interaction data presented in matrix form.
DT-Hybrid integrates biological knowledge and the bipartite interaction network into a unified framework.
Nestedness is a statistical measure used to interpret bipartite interaction data in several ecological and evolutionary contexts, e.g. biogeography (species-site relationships) and species interactions (plant-pollinator and host-parasite networks).
Our structural analysis demonstrated that both VIM and SHP motifs contributed to Cdc48 binding, suggesting a bipartite interaction mechanism, a characteristic mode of binding of common Cdc48 adaptors (Bruderer et al., 2004; Yeung et al., 2008).
FALCON operates on any form of bipartite interaction data represented as a matrix of associations and is set up to be deliberately 'blind' to the source and interpretation of input data.
To quantitatively assess the effect of this bipartite interaction with physiological concentrations of SroC and GcvB, we introduced scar-less point mutations of C63G/C87G (sroC**) in the chromosomal gltI- sroC locus and determined the half-life of GcvB.
The drug-target network is defined as a physical bipartite interaction network where the color-coded nodes denote herbal drugs (purple) and their target proteins (green), and an edge links a drug node to a protein node if the protein is the target of the drug.
Similar to Gln61 in the RasGAP-Ras complex, Gln70 in the LepBdrancourtii GAP domain-Rab1 complex also mediates bipartite polar interactions with equatorial fluoride ion and the putative nucleophilic water.
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