More COG groups in 'secondary metabolites biosynthesis, transport and catabolism' possess high DDs, which may indicate that these members are active in the thirteen M. tuberculosis strains.
Consequently, the two differentially expressed SUS genes, Pt- SUS1 (NW > OW > TW) and Pt- SUS2 (OW > TW > NW), identified in our study have opposite expression patterns, which may indicate that different SUSs have different functions in cellulose biosynthesis.
The CP_0597 gene resides next to this guaBA- add cluster, which may indicate that this gene may also be involved in purine biosynthesis.
Insulin also stimulates testosterone biosynthesis, which may account for the higher testosterone levels seen in this group of patients.
Increased NADPH biosynthesis may indicate increased source of reducing equivalents and an improvement of the anti-oxidant defence through the proxiredoxin, thioredoxin, and glutathione systems.
It activates redox homeostasis by the glutathione/glutaredoxin system as well as the flavonoid biosynthesis pathway, which may enhance the biosynthesis of antimicrobial flavonoid phytoalexins [ 26].
The naturally occurring C/C isotope ratios of individual lipids have previously been used to discriminate between different pathways of lipid biosynthesis [ 46] and may indicate the pathway of PUHC biosynthesis.
The significant over-representation of the GO-terms 'metabolism', 'biosynthesis' and 'macro-molecule biosynthesis' (Fig. 5) may indicate that also in zebrafish adipocyte-development is ERK1 dependent which would be in line with our suggestion, that role for ERK1 becomes more dominant at later developmental stages (Fig. 2).
We also identified species differences in plant hormone biosynthesis pathways, which may contribute to varying degree of disease symptoms.
Given that the same conditions activate the CoQ biosynthesis pathway [ 30], this may indicate a connection between CoQ biosynthesis and respiration.
