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Proteins involved in the viral biosynthesis were shown to harbor PrDs as well.
S. sclerotiorum mutants deficient in oxalate biosynthesis were shown to be less pathogenic than wild-type fungus, and enhancement of H2C2O4 degradation capacity was shown to enhance plant resistance to S. sclerotiorum [ 3- 5].
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A new class of steroidal therapeutics based on phylogenetic-guided design of covalent inhibitors that target parasite-specific enzymes of ergosterol biosynthesis is shown to prevent growth of the protozoan-Trypanosoma brucei, responsible for sleeping sickness.
Moreover, linolenic acid (a precursor of JA biosynthesis) was shown to induce the laticifer differentiation of H. brasiliensis [ 71, 72].
NAC transcription factor PtrWND1B / PtrSND1-A2, whicontrolsolsecondaryry wall biosynthesis, was shown to undergo AS in Populus[ 17, 18].
Moreover, a decrease in GSH induced by inhibition of GSH biosynthesis was shown to alter the NF-kB activation responses to LPS [ 54] or TNF-α [ 55].
Brain specific depletion of desat1, which encodes a desaturase enzyme involved in pheromone biosynthesis, was shown to alter pheromone production (Bousquet et al., 2012).
Since desferrioxamine biosynthesis was shown to be highly responsive to iron concentrations, the effects of iron in three growth media (ASW-A, ASW-K, and DI-A) (see recipe in Table S3 in Supporting Information) on desferrioxamine production was investigated.
Scopoletin and scopolin biosynthesis was shown to be strongly dependent on the CYP98A3 [ 14], which is the cytochrome P450 catalyzing 3′-hydroxylation of p-coumarate units in the phenylpropanoid pathway [ 33].
These three biosynthesis genes were shown to be physically linked in a penicillin biosynthesis gene cluster (pcbAB-pcbC-penDE) [ 7, 10- 13].
UV induced activation of MAPK and expression of PA biosynthesis genes were shown to be inhibited with staurosporin and MAPK inhibitors.
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Justyna Jupowicz-Kozak
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