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The first committed step of artemisinin biosynthesis is the cyclization of farnesyl diphosphate by a sesquiterpene synthase to produce an amorphane-type ring system.
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The first dedicated step in lutein biosynthesis is the ε-cyclization of lycopene by LCY-e.
The first committed step in biosynthesis of all cyclic sesquiterpenes and STL is the cyclization of FDP by sesquiterpene synthases in the cytosol [ 24, 25, 27, 28].
Background: The committed step in the biosynthesis of the anticancer drug taxol in yew (Taxus) species is the cyclization of geranylgeranyl diphosphate to taxa-4 5),11(12)-diene. taxa-4 5
Some candidate genes likely to be involved in hydroxylation or glycosylation of aglycones for triterpene saponin biosynthesis are cytochrome P450s (CYP450) and glycosyltransferases (GT), but no candidate has been identified for the cyclization step [ 17].
Further work on sterol biosynthesis demonstrated that lanosterol is the product of squalene-oxide cyclizaton in organisms of a nonphotosynthetic lineage and cycloartenol is the product of squalene-oxide cyclization in organisms of a photosynthetic lineage.
The cyclization of oxidosqualene is the branch point for the biosynthesis of ginsenosides and plant sterols.
The cyclization of oxidosqualene is the branch point for the biosynthesis of mogrosides and sterol.
The cyclization of oxidosqualene is the branch point for the biosynthesis of ginsenosides and phytosterols.
t is the product of a cyclization and has one child, or (ii).
The cyclization of 2,3-oxidosqualene is the branch point of sterol and ginsenoside biosynthesis and controls the carbon flux through the branched biosynthetic pathways.
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