Sentence examples for biosynthesis by blocking the from inspiring English sources
The compound 26-fluorolanosterol (26FL) inhibited ergosterol biosynthesis by blocking the target enzyme sterol C24-methyltransferase as per GC MS analysis of their neutral lipids' fraction [84].
Furthermore, disruption of the ANT genes in yeast resulted in a reduction of haem biosynthesis by blocking the translocation of haem precursors into the matrix.
PPAR γ ligands inhibit estrogen biosynthesis by blocking the cytochrome P450 [ 100].
For example, the drug abiraterone, which potently inhibits both endocrine and autocrine/paracrine testosterone biosynthesis by blocking the activity of the enzyme cytochrome P450 CYP16, 16 has been shown to improve survival in men with metastatic CRPC (mCRPC) after failure of the chemotherapeutic agent docetaxel.
Gabaculine acts as a tetrapyrrole biosynthesis inhibitor by blocking the glutamate-1-semi aldehyde aminotransferase activity [ 30, 31].
Bisquaternary ammonium salts that mimic the structure of the phospholipid precursor choline have been shown to target membrane biogenesis in P. falciparum by blocking the biosynthesis of PC.
Inhibition of S. aureus diapophytoene desaturase (CrtN) could serve as an alternative approach for addressing the tricky antibiotic resistance by blocking the biosynthesis of carotenoid pigment which shields the bacterium from host oxidant killing.
The production of fatty alcohols could be significantly increased by blocking the hydrocarbon biosynthesis pathway.
Itraconazole and related azole derivatives act by blocking the ergosterol biosynthesis pathway through the inhibition of the fungal cytochrome P450 enzyme lanosterol demethylase (Erg11) [ 7].
Based on this knowledge, it is conceivable that in the present patient, who had a background of portal endothelial inflammation maintained by chronic HCV infection [ 17], indomethacin did precipitate PVT by blocking the endothelial biosynthesis of prostacyclin.
Bisphosphonates inhibit osteoclast formation by blocking the mevalonate pathway of isoprenoid biosynthesis.
