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The top scoring clusters included processes related to the biosynthesis and processing of nucleotides, RNA, proteins and ATP, and to transport, proteasome and metabolism.
Many inhibitors have been identified that interfere with glycoprotein biosynthesis and processing of N-glycans.
The snoRNAs expressed from the intronic regions of GAS5 are involved in the biosynthesis and processing of ribosomal RNA, which has always been assumed to be an essentially housekeeping role.
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The Al-induced down-regulation of many proteins involved in protein biosynthesis and processing, which are the major consumers of ATP and nutrients, indicated that the translation was reasonably regulated to save energy and nutrients in roots, especially in the Al-tolerant species.
This protein complex not only ensures efficient mRNA cleavage and polyadenylation, but also links 3′end formation to other steps of mRNA biosynthesis and processing (Shi et al, 2009b).
Previously, through our investigations in S. cerevisae, we described a large set of coregulated genes - the ribosome and rRNA biosynthesis (RRB) regulon – whose products function in various levels of rRNA and ribosome biosynthesis and processing.
These inhibitors aim at (i) reducing inflammatory processes associated with fibrosis, (ii) inhibiting biological functions of cytokines and growth factors that promote fibrosis, (iii) reducing cell proliferation, and (iv) decreasing the biosynthesis and enzymatic processing of procollagen molecules.
Our GO analysis shows that CR results in relative upregulation of genes within GO categories associated with ribosomes, translation initiation and elongation, and protein biosynthesis, suggesting that protein biosynthesis and processing machinery remain at fairly high levels.
Yeast NOP2 is required for correct rRNA biosynthesis and processing [ 14] and nop2 mutants are lethal.
The ER is responsible for the synthesis, modification, and processing of proteins, the chain folding, assembly, and transportation of new peptides, the biosynthesis of steroids, cholesterol, and many lipids, and intracellular calcium regulation.
Each gene cluster encodes proteins involved in energy provision for active transport, membrane pore formation and protease processing, which assembles to form a dedicated biosynthesis, transport and processing system for the secretion of the potent T-cell antigens belonging to the ESAT-6 protein family [ 1- 9].
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