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All biopsies were reported as normal for H&E histology.
Prior liver biopsies were reported in about 2·0% of patients.
All biopsies were reported by specialist paediatric histopathologists from the same tertiary centre.
Only 2% of all the oesophageal biopsies were reported as normal.
All biopsies were reported using the CIN classification by a consultant histopathologist, with over 15 years experience, who was blinded to the results of the cytological tests.
Colposcopy directed biopsies were reported as a diagnosis of Normal, Cervical Intraepithelial Neoplasia 1 (CIN 1), Cervical Intraepithelial Neoplasia II (CIN 2), and Cervical Intraepithelial Neoplasia 3 (CIN 3).
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It is notable that additional histological analysis from surgical lung biopsies was reported in 34.1% of patients, even in those with a definitive UIP pattern on HRCT.
14 Data regarding biopsies are reported online to the Danish National Pathology Registry DNPRR), which contains detailed records of all cytological and histological specimens analyzed in Denmark since 1997.
Recently, the utility of a mtDNA deletion for molecular definition of benign, malignant and proximal to malignant prostate needle biopsies was reported [ 23].
There may be inter-observer variation influencing the Melbourne data as ∼50% of biopsies are reported by community pathologists, whereas all RP specimens are read by two specialist uro-pathologists.
The positive predictive value with regard to the detection of additional malignancies for ultrasound prompted biopsies was reported or was able to be inferred from the given data in four of the six studies.
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