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Many extracellular biophysical stimuli could affect GAG synthesis by cells.
Mesenchymal stem cell (MSC) differentiation can be influenced by biophysical stimuli imparted by the host scaffold.
Biochemical and biophysical stimuli of cell growth and differentiation are regarded as potent tools to improve bone formation in vitro.
Biophysical stimuli are important to the development and maintenance of cancellous bone, but the regulatory mechanisms need to be understood.
In vitro manipulation of the response of cells to their biochemical and biophysical stimuli is a critical process in regenerative engineering.
A number of preconditioning approaches have been suggested to improve the regenerative potential of EPCs, including the use of biophysical stimuli such as shear stress.
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The mechanoregulation algorithm employed determines tissue differentiation both in terms of the prevailing biophysical stimulus and number of precursor cells, where cell number is computed based on a three-dimensional random-walk approach.
Fluid shear is a well-defined biophysical stimulus for in vitro studies of mechanotransduction of articular chondrocytes.
While some experimental data are associated with dissection of the abdominal aorta [ 24], other studies provide evidence for structural differences between the thoracic and abdominal aorta which in addition to different biophysical stimulus makes them not well comparable [ 25].
The differentiation of SSCs/BMSCs is dependent on exposure to biophysical and biochemical stimuli that favor early and rapid activation of the in vivo tissue repair process.
Employing biochemical, biophysical, and mechanical stimuli generated robust hyaline articular cartilage with a tensile modulus of 2 MPa and a compressive instantaneous modulus of 650 kPa.
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