These examples show how selected advanced biophysical methods can greatly increase our understanding of the system under investigation; in turn, this insight may be used to improve formulation design.
Incorporating functional constraints into flexible backbone design should help to achieve challenging engineering goals that exploit the role of conformational variability in controlling biological processes, while more generally advancing biophysical understanding of the relationship between variations in protein sequence, structure, dynamics, and function.
In recent years, biophysical techniques have advanced to face the challenge of studying membrane bound GPCRs.
In parallel with the development of methods to study the functions of lipids directly in the cell membrane, advances in biophysical techniques to study cell mechanics with enhanced resolution will be needed to conclusively understand the mechanical roles of different cellular and membrane compartments during division.
She received a Ph.D. in biophysics and biophysical chemistry from Johns Hopkins University.
Unlike foot racers, who appear to be approaching their absolute biophysical limits, speed skaters keep advancing by leaps and bounds.
Polymers isolated from patients homozygous for the Z allelle have an unbranched beads-on-a-string morphology [ 11, 12], and several hypotheses as to the underlying inter-molecular linkage have been advanced based on biophysical [ 11– 14] and crystallographic [ 15] evidence.
We discuss recent technical advances in computational and biophysical chemistry, which have provided us with new ways to dissect evolutionary processes.
Recent advances in microscopy techniques and biophysical measurements have provided novel insight into the molecular, cellular and biophysical basis of cell adhesion.
Recent crystallographic, structure-guided biophysical and cell-based studies have advanced our understanding of how Wnt signalling is regulated at the cell surface.
