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These two biomarkers were derived using distinct methodologies: one using a linear risk-score analysis and the other using gradient-descent-based optimization.
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The resulting cut points for the CSF biomarkers are similar to those reported by Shaw et al. (2009), which were derived using a maximum accuracy classification of autopsy confirmed Alzheimer's disease versus healthy controls.
Models were derived using backwards selection.
Based on lipidomics in the biomarker-discovery series, a predictive model comprising a lipid triplet (TG[16:0/18:0/18:1], phosphatidylcholine [PC][18 1/22 6], PC[O-24:1/20:4]) was derived using an evolutionary algorithm.
Because biomarkers are derived from biological precursor molecules in specific organisms, and because each of these organisms lives only under certain environmental conditions, it is logical to use biomarkers as indicators of those conditions (Bjorøy et al. 1992).
The biologic model under which biomarkers are derived may have a significant impact on the conclusions that we draw about a particular biomarker.
Area under the curve (AUC) biomarker levels were derived and expressed as 1,000 h units l−1.
Why did no other biomarkers, many of which were derived from collagen, show association?
EF improves significantly when the early diagnostic biomarkers reported in the literature were exclusively compared with the best discriminative genes derived using ECD and the alternative signatures.
Biomarkers were eligible regardless of whether they were derived from blood, urine, tissue, or imaging.
Of the 145 gene expression biomarkers derived from the early sepsis equine model, 408 probesets were derived.
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