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Currently, much attention goes to biomarkers that are able to detect AKI in an earlier phase of development.
The study may also identify biomarkers that are able to suggest which patients are more likely to respond to sGC stimulators.
The major challenge and key step for cancer therapy is to identify the target that is essential for the survival and proliferation of the cancer cells, as well as biomarkers that are able to predict what types of cancers are sensitive or resistant to specific inhibitors.
Thus, there is a pressing medical need to identify minimally invasive biomarkers that are able to identify early stages of CAN at a time that changes in therapy may alter outcomes.
In addition, biomarkers that are able to subgroup tumors based on aggressivity, thus aiding in clinical decisions, were also identified.
As a consequence, biomarkers that are able to classify tumors and are coherent with patient survival are desperately needed [ 2].
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The focus of the present study was to design a framework for identification of biomarkers that were able to predict the robustness status of mild stress adapted cells.
A study by Lu and coworkers identified a set of biomarkers that were able to distinguish between methicillin resistant and vancomycin-intermediate S. aureus (VISA) strains and vancomycin-susceptible S. aureus strains, as well as between SCCmec types IV and V isolates and SCCmec types I III isolates [ 151].
ER status was selected as it is a clinical used biomarker that is able to divide breast tumors into two clinically important and clearly distinguishable groups of cancers.
In this study, the elevation of NGAL was found to be a suitable biomarker that is able to detect at an earlier time point than serum creatinine in dogs with postoperative AKI.
Thus, a biomarker that is able to detect the early onset of a side effect, such as bone marrow suppression before a detectable decrease in WBC count, would allow the patient to receive more appropriate treatment (e.g., strict anticancer dosage control and/or prophylactic administration of hematopoietic drugs).
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