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In the present study we evaluated several indices of As exposure, as well as As metabolism, in relation to results of lung function testing and a biomarker of lung function (CC16).
The significant associations between serum CC16 and FEV1/FVC reinforce the fact that serum CC16 is a biomarker of lung function, and it may be useful in assessing early respiratory damage induced by As, especially among individuals with skin lesions.
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We also explored the effect of these biomarkers on lung function multivariable regression based on models that have been optimized previously for this cohort (Tager et al. 2005).
The objectives of the present study were (1) to perform a controlled human exposure study of lung function and biomarkers of pulmonary epithelial integrity in volunteers before and after exposure to indoor swimming-pool environments.
Beyond asthma and CF, circulating YKL-40 has been further associated with decline of lung function in the general population and has been proposed as a biomarker of susceptibility to the long-term effects of cigarette smoking [62].
Considering the reduced rate of lung function decline in postmenopausal patients, future studies will likely require enhanced study designs, such as selective enrollment of those with prognostic biomarkers predictive of decline.
Long-term exposure can permanently damage lung tissue and result in the loss of lung function.
Consider just one effect: decline of lung function.
An additional limitation of our approach involves the use biomarker and gene expression data as markers of exacerbations in the past year, yet this may indicate a stable molecular signature differing from that of lung function and other markers of severity.
Longitudinal assessment of lung function (FEV1 and peak flow) and symptoms were undertaken, with event studies of high pollution on biomarkers of exposure (urinary 1-hydroxypyrene) and effect (exhaled breath condensate (EBC) pH and hydrogen peroxide concentration).
These serum biomarkers may likely reflect the pathogenesis and progression of CWP in coal workers, and may provide for the importance of serum indicators in the early diagnosis of lung function injury in coal miners.
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