Additional funding was provided by the Development of an Integrated EMSL MS and NMR Metabolic Flux Analysis Capability In Support of Systems Biology: Test Application for Biofuels Production intramural research project from EMSL to N.G.I.
The relative lack of success of T-cell-directed therapies stimulated research into alternative methods of targeting T-cell biology, including T-cell co-stimulation; of the multiple co-stimulatory pathways that can upregulate or downregulate T-cell activation, one of the best characterized is that between CD28 and CD80/CD86 (B7 molecules).
His research focuses on various aspects of T-cell biology, including T-cell receptor (TCR)–CD3 signalling and cell biology, the development and function of regulatory T cells, and type 1 diabetes.
Hematopoietic Stem Cell Transplantation reviews pertinent aspects of both autologous and allogeneic stem cell transplantation and our current understanding of transplantation biology including T cell and natural killer cell biology, HLA expression, and post-transplant immune reconstitution.
As an immunologist, my own research focused on the biology of T lymphocytes--key players in fighting infection, destroying tumours, and rejecting transplants.
In recent years, growing interest has been focused on mitochondrial biology in T cells.
The genetics and molecular biology of T-ALL.
Gp120 induced caspase 8 dependent NF-κB activation is a novel pathway of HIV replication which increases understanding of the biology of T-cell death, as well as having implications for understanding treatment and prevention of HIV infection.
This is a novel biological finding with importance for the biology of T-cell leukemia.
The EU FP7 large integrated project SYBILLA (Systems Biology of T-ce ll Activation in Health and Disease) coordinates such an endeavor.
Also as seniors, students who completed the revised curriculum scored higher on the standardized Biology Field Test.
