YJT contributed towards all the molecular biology works, cell disruption experiments, acquisition of data and data analysis and interpretation of the study.
NIEHS scientists have contributed much toward understanding basic biology, genotoxicity, endocrine disruption, cell signaling, and oxidative stress, as well as to public health through understanding of morbidity and mortality of air pollution.
Our laboratory is applying this and other custom microarrays to many areas of toxicology, including endocrine disruption, receptor biology, stress response and the effect of toxicants on immune function.
The acetylation of 2′-OH groups may alter the ability of a RNA to fold properly and ultimately result in an incorrect conformation and therefore disruption of biology.
A previous study revealed that the amplitude from the cartilage surface is related to the tissue reflection coefficient, acoustic impedance, elastic modulus and surface condition in physics, and related to proteoglycan depletion and collagen disruption in biology [ 28- 30].
Disruption of macrophage biology has been linked to increased pathogen infection, inflammation and malignant diseases.
Consistent with a role for neuronal signaling in regulating pancreatic biology, we previously found that disruption of sympathetic innervation in mice leads to abnormal islet structure and loss of functional maturation (Borden et al., 2013).
Recognition that the carcinogenic effects of environmental toxicants may originate in disruption of mitochondrial biology could prove important for the future development of cancer prevention and treatment procedures related to TCDD and other dioxin exposures.
Interactions with HS are known to promote oligomerization of certain chemokines (6), and disruption of this biology has been postulated as a mechanism for their actions in in vivo models (2).
The disruptions to human biology that underlie the association between alcohol and these conditions bear exploring.
