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They conclude that plant-based platforms are most beneficial for the production of biologics that require high quantity, rapid production speed, complex post-translational modifications, or oral delivery.
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This suggests a unique biologic mechanism that requires further elucidation.
Although fracture healing is a highly ordered biologic process that requires precise temporal and spatial regulation, it is known that various compensatory mechanisms have evolved to rescue healing under adverse conditions.
Thus, proteins that require such modification for biologic activity should be studied in their myristoylated form.
Whether BAHTs exert in vivo biologic activity and, even if so, what fraction of total 'BLyS' biologic activity is exerted by BAHTs rather than by BLyS homotrimers remain open questions that require resolution.
The problem for the industry is that producing biologics requires a lot more know-how than the production of traditional drugs such as aspirin, which are based on chemistry.
To include this kind of "etiologic case" (as Greenland and Robins call it) in the total burden of the exposure seems appropriate, although that would require strong biologic assumptions.
Both small molecular drug and biologics will require a certain level of photostability studies.
Both small molecular drug and biologics will require a certain level of photostability studies In-use photostability studies are required for topical drug products as they are applied to external body surfaces, thus, they have the potential to be exposed to a significant amount of light during use by the patient.
However, the coming tide of biosimilars and follow-on biologics will require considerably better glycan characterization.
However, the possibility that VEGFRs require SFKs to mediate their biologic effects in other tumours has not been established.
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