In other words, the treatment with the ZSCAN4 biologics changed cells with homogeneously trisomy 21 into a mosaic of cells with trisomy 21 and cells with a normal karyotype.
The result of this mineralogic control on the preservability of organic remains in the rock record is that the geologic time scale essentially a measure of biologic changes through time takes in only the last 13 percent of Earth history.
Despite efforts from advocacy groups and individual patients to increase awareness — as well as empirical evidence linking psychiatric disorders and treatments to biologic changes in the brain — there's the nagging sense that many psychiatric diagnoses may be arbitrary and subject to social conventions, or that many affected patients could, with a little willpower and hard work, get better.
Post-glacial environmental changes were identified as stratigraphic or biologic changes in select cores.
Most other phenomena will be transient (e.g., distal groundwater responses), not uniquely diagnostic of earthquakes (e.g., flooding), or more ambiguous (e.g. biologic changes).
Findings showed in experimental animal models, in their general concept about the progressive biologic changes that develop in the transplanted semitendinosus tendon, could be useful to lead ACL reconstruction in pediatric and adolescent population.
The presence of resident progenitor cells with multi-differentiation potential in the human tendon [24] and local release of bone morphogenic proteins (BMP) which helps in differentiation of pluripotent mesenchymal cells into osteoblasts [25, 26] has been noted after acromioplasty and in cases with degenerated cuff tissue; these biologic changes may thus induce ectopic bone formation [22, 27].
Calls to start school later are based on well-documented biologic changes during puberty that shift sleep cycles later than those of younger children or older adults.
Since biological processes are mediated by multiple genes working in synchrony and genes are co-regulated, pathway analysis is more conclusive regarding biologic changes.
Each puff of cigarette smoke contains >1014 oxidant molecules and >1000 xenobiotics [2], and exposure to cigarette smoke evokes significant biologic changes in the airway epithelium, even though many smokers are phenotypically normal [3] [6].
