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In larger populations, any specific allele is carried by so many individuals that it is almost certain to be transmitted by some of them unless it is biologically unfavourable.
Mechanical stresses were therefore able to build up in the vicinity of the unfilled Combi-hole, surrounded by a biologically unfavourable environment.
Importantly, the low CbG expression observed in each of the cell lines is also analogous to the CbG levels found in clinically and biologically unfavourable NB tumours (Hettmer et al, 2003).
Here, we demonstrate that low CbG levels in some NB cell lines are analogous to the ganglioside pattern observed in clinically and biologically unfavourable NB tumours, providing an in vitro model to study pharmacological agents that might alter the metabolism of complex ganglioside subspecies.
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This notion is supported biologically by its association with unfavourable primary tumour characteristics such as advanced tumour stage, as shown in both our current study and previous work in breast (Xu et al, 2011b) and endometrial cancer (Supernat et al, 2012).
Since vitamins and minerals are biologically active, both their deficiency and excess have unfavourable influence on human health, especially in childhood when providing adequate vitamin and mineral intakes is crucial for the child's physical, motor, mental and emotional development.
However, it seems biologically plausible that the combination of NAT2 and SULT1A1 'fast' genotypes is unfavourable.
Although most of the cases detected by the MSPN had biologically favourable factors, such as no-deletion of 1p and low expression of the TRK-A gene, some cases with unfavourable prognostic factors have been reported (Matsunaga et al, 2000; Tajiri et al, 2001).
Not biologically.
An unfavourable polling result, perhaps.
Unfavourable stories invite libel suits.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com