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What constitutes a phenotype should reflect a biologically relevant level of detail consistent with the particular risk comparison being made.
In addition, we show that intrinsic noise is not sufficient to induce the observed level of cell-to-cell variability of apoptosis response at biologically relevant level of molecular numbers, while the extrinsic noise of protein variations is plausibly the main source giving rise to the degree of heterogeneous responses of intrinsic apoptosis pathway between single cells.
By including all available functionally related paralogs for each structural gene in the two-component analysis, this not only improved the statistical power, but also put a biologically relevant level of variance into each of the possible gene states, thus accounting for temporal gene variation whilst enhancing the boundaries of this clustering approach.
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Genetically modified Sertoli cells retained their immunosuppressive ability in vitro, based upon lymphocyte proliferation assays, and were capable of generating biologically relevant levels of NT-3.
It has been found that bioactive glass surfaces can release biologically relevant levels of soluble ionic forms of Si, Ca, P, and Na, depending on the processing route and particle size.
Biologically relevant levels of the biomarkers existed among girls in the cohort.
Biologically relevant levels of hemoglobin, triolein, bilirubin, and rheumatoid factors did not interfere with the recovery of NGAL.
Our observations suggest that biologically relevant levels of antigens, including endotoxin, may have been transferred to the recipient.
Human exposure to biologically relevant levels of ozone is clearly linked to respiratory illnesses, such as asthma.
We report here that biologically relevant levels of Cd (≤ 50 μM) (Apostolova et al. 2006) alter the biotransformation of carcinogenic AAs through impairment of NAT enzyme functions.
As proposed in the lacZ system, gene amplification could initially provide the means to reach biologically relevant levels of protein functionality, before neofunctionalization occurs.
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