To be able to employ the most suitable co-expression distance measure for our analysis, we evaluated the ability of four popular gene co-expression distance measures to detect biologically relevant interactions between pairs of genes.
Although the explanation for these patterns of antagonism remains unclear, the presence of non-random patterns, potentially dependent on the ant host (genus: Fig. 3; species: Fig. 4) or geographic location (Fig. 4), suggests underlying biologically relevant interactions that the extent of our evaluations could, however, not elucidate on.
This confirmation demonstrates that the employed inference approach is capable of identifying biologically relevant interactions.
In this contribution we discuss the particularities of RNA based systems and discuss our approach for developing a general method applicable to the different realms of chemistry in biologically relevant interactions.
It is noticeable that all significant trans effects are observed with common variants located within genes instead of gene deserts, suggesting biologically relevant interactions.
This shows that our modelling approach is capable of finding de-novo biologically relevant interactions.
Hence, in order to determine the external validity of the behavioral phenotypes while at the same time revealing biologically relevant interactions [34], [35], we intended to pursue our research objective with a 2×2 factorial design [36].
Likewise, the inability of any one technique or particular screen to detect all biologically relevant interactions suggests that combining datasets increases coverage.
To improve biologically relevant interactions both for binding and release by tissue heparanase, there is a shift away from using heparin as a global substitute in favor of more biologically appropriate forms of heparan sulfate (Whitelock and Iozzo 2005).
The biologically relevant interactions between morphogens and heparan sulfate are optimized by nature for both binding and release, and depend on the precise micropatterned structures of 2- and 6-O-sulfate moieties of heparan sulfate chains (Ashikari-Hada et al. 2004).
