S100A8 and S100A9 form heterodimers, which are the biologically relevant forms of these proteins and have pleiotropic properties [9], [10], [11].
The analysis is focused on the biologically relevant forms of Ins(1,3,4,5,6) P 5 and allow further insights into the structural and energetic factors associated with the microprotonation sequence, the conformational change and the coordination properties displayed by this Ins P 5.
Future studies aimed at identifying the mature, in vivo form of PPAD and its enzymology are required in order to pin down the biologically relevant form of the enzyme and as such the more appropriate target for therapeutic blockade.
We reason that these divergent lines of evidence could suggest that the ATP-induced allosteric effect of 5-LOX we have characterized herein may be another biologically relevant form of 5-LO Xregulation through which inflammation control can be modulated.
Our integrated approach enhances existing phosphorylation event representation by providing a framework for the definition and annotation of biologically relevant phosphorylated forms, including multiply phosphorylated forms.
The phosphorylation networks we construct, centered on the human checkpoint kinase BUB1B (BubR1) and its yeast counterpart MAD3, offer a unique view of the spindle checkpoint that emphasizes biologically relevant phosphorylated forms, phosphorylation-state specific phosphorylation-state specifictionshiPPIs
The algorithm compensates for the different background frequencies of SCNAs of varying length and quantifies the likelihood of copy-number alterations being biologically relevant in the form of a q-value.
As a biologically relevant and prevalent form of genetic variation [ 39], more than 800,000 InDels in a diverse population have been mapped to known genes, some of which can be associated with genetic diseases [ 40, 41].
Although the focus of most variant-calling software has been on detecting SNVs, it is the case that large-scale structural copy number variants and small indels are known to also be a biologically relevant and prevalent form of genetic variation [ 40, 41].
It has been found that bioactive glass surfaces can release biologically relevant levels of soluble ionic forms of Si, Ca, P, and Na, depending on the processing route and particle size.
> -wrap-foot> ourrall, our method captured almost all of the human BUB1B phosphorylation sites present in other phosphorylation site databases with the added advantage that we could define BUB1B multiply phosphorylated forms carrying biologically relevant combinations of sites.
