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Place-based stressors are biologically relevant components of the human environment and can function independently of individual-level stressors to determine health (Diez-Roux 1998; Shenassa 2001).
Our aim was to scrutinize the expression patterns of several of the most biologically relevant components of the NFκB route in intestinal biopsies from active and treated patients and after in vitro gliadin challenge, and to assess normalization of the expression using an inhibitor of the MALT1 paracaspase.
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Serum and these supplements contain ECM proteins, growth factors and other biologically relevant components that have impeded our understanding of the specific mechanisms by which stromal cells contribute to the acquisition and loss of ovarian hormone responsiveness.
An additional step is added between Step 4 and Step 5 to ensure that the identified systems components are more strongly linked to the phenotype through comparative analysis of biological networks (Detecting biologically relevant component interplays through biological networks section).
It provides better coverage of the biologically relevant part of the protein conformation space.
To remove this biologically relevant variation component from the GAPDH and B2M expression, we identified a set of transcripts that correlated with the geometric mean of B2M and GAPDH expression at a 5% FDR (false-discovery rate).
Whether the SOD1 reactivity present in these structures is indicative of a biologically relevant concentration of the protein or is some non-specific interaction with other components of the structure is unknown.
Therefore, the identification of biologically relevant genes is of fundamental and practical interest.
These should be fully sequenced to facilitate extraction of biologically relevant knowledge out of CSH.
Statistical factor analysis methods have previously been used to remove noise components from high-dimensional data prior to genetic association mapping and, in a guided fashion, to summarize biologically relevant sources of variation.
The water-soluble fraction of inhaled PM is more biologically relevant because its components could more easily reach pulmonary vessels than can whole particles or the insoluble fraction (Li et al. 2005).
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