In Eqs. 3 and 4, (y_i) and ({hat{y}}_{i}) are the measured and predicted biologically associated values for compound i, respectively, and (bar{y}) is the mean of all activities from the compounds in the data set.
Further work to biologically validate our predicted modules is needed to gain a more complete picture of the regulatory process in the TNBC sub-type.
We have also preformed a GO and pathway based study to biologically validate the predicted complexes.> Columns 3 and 4 of Table 4 represent predicted complexes and the list of proteins that are matched with some real one, respectively.
We show that the method provides comparable or better predictions on recently experimentally-determined PPIs than several existing methods and that such predictions are biologically plausible using the predicted interactomes of A. thaliana, P. trichocarpa, M. musculus, H. sapiens, and S. cerevisiae.
Noteworthy, molecular modeling correctly predicted the biologically active enantiomer of 2,4-dihydropyrano[2,3-c]pyrazoles 2,4-dihydropyrano[2,3-c]pyrazoles 2,4-dihydropyrano[2,3-c]pyrazoles
The biologically based model successfully predicted the growth of normal and arsenic-treated cells, as well as the senescence rates.
Five patients were treated at the starting and predicted minimal biologically effective dose of 50 mg/day.
Highly biased sex ratios are predicted for biologically realistic values of parameters corresponding to low female philopatry and moderate difference in habitat quality.
Indeed, for all the RP families, the biologically significant sites were predicted in the deduced amino acid sequences using the program PROSITE.
Using 80 clusters of tightly coexpressed genes in 38 hematopoietic cell types [14], we demonstrated that the transcriptional control mechanisms predicted are biologically coherent, and that GSCA performs better than current methods.
