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As a result, sustained oscillation can occur at much more biologically plausible values of n1, n2; e.g. (n1, n2) = (3, 3) or (2, 4), indicated by the dots in Figure 12b.
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These analytical and simulation results of a trait evolving under stabilizing selection use biologically plausible parameter values with a level of mutational bias similar to our observations (κ = 2−4).
We further explore the applicability of our conclusions to a more general context (i.e. to other cell types) by running global sensitivity analysis and exploring the behaviour of the model solution in the wide range of biologically plausible parameter values.
We established a minimal mechanistic model of ER-dependent gene expression, that predicts complex non-linear effects in transcriptional response to tamoxifen in the broad range of biologically plausible parameter values.
To extend our conclusions to other cell types we ran global sensitivity analysis and explored model behaviour in the wide range of biologically plausible parameter values, including those found in cancer cells.
The measurements recorded are also highly biologically plausible, in terms of the very small proportion of misclassifications and values ≥44 weeks.
A more biologically plausible development of the model presented here is also discussed.
"... The model by Rubin and Terman represents one of the most comprehensive and biologically plausible models of DBS published recently.
A new biologically plausible model of visual selective attention is developed based on synaptically coupled Hodgkin–Huxley neurons.
The model is an existence proof for a biologically plausible implementation of a neural blackboard central pattern generator.
The biologically plausible mechanism of glutathione depletion in airway mucosa.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com