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However the comet data give valuable proof-of-principle that TP300 is damaging DNA, but the semi-quantitative nature does not allow a biologically optimal dose of TP300 to be identified.
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Antagonism was seen at higher concentrations of EGFR and PI3K inhibitors and suggests that there may be a biologically optimal dose beyond which activity is lost.
Because immune-modulating agents do not directly target tumor cells, determining the biologically optimal dose is a complex issue.
All patients receiving postoperative radiotherapy received an optimal dose of radiation (a biologically equivalent dose of 50 60 Gy in 2-Gy fractions) [ 20, 21].
And a genetic test might help doctors determine the optimal dose of warfarin, a blood thinner used by millions of Americans.
The optimal dose of targeted treatment in oncology may not be the maximal tolerated dose.
Preliminary experiments were performed to define the optimal dose of PIs (Fig. S2).
69 Thus the optimal dose of multidisciplinary rehabilitation remains unknown.
The optimal dose of cell therapy currently remains unclearly defined.
The optimal dose of daptomycin is still unknown.
The optimal dose of radiotherapy is yet to be found.
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