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While this shows a solid common core of regulated genes, gene lists per se are not suitable for evaluation of the biologically meaningful differences between the resulting lists.
Seven GEX modules associated with key biological processes in FBC (tumor invasion and metastasis, immune response, angiogenesis, apoptosis, proliferation, and ER and HER2 signaling, respectively) were used to discover biologically meaningful differences between MBC subgroups and to compare them with the intrinsic subgroups of FBC [ 21, 32].
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Alternatively, it may reflect a biologically meaningful difference between various lineages.
The latter, together with other uncertainty factors discussed above, suggests that caution is warranted before concluding that there are biologically meaningful differences in selective constraints between angiosperms and gymnosperms.
In short, comparisons between the monodominant and mixed forests at top soils and deep soils show no significant or biologically meaningful differences in their soil properties.
Finally, we asked whether enhancement of Meis binding in the IIBA reflects biologically meaningful differences in the branchial arches.
There were few biologically meaningful differences in the subject characteristics, although, large sample sizes allowed significance to be seen with some minor differences.
To determine whether the clusters discovered have biologically meaningful differences, we correlated the available disease outcome parameters (overall survival and time to recurrence) with the cluster distribution of samples and found a significant difference in clinical outcome between samples assigned into different clusters.
Thus, our estimate of the number of SNPs is a conservative one but is more likely to represent biologically meaningful differences.
Second, strains may actually exhibit biologically meaningful differences in expression (e.g. a gene may be highly expressed in the midgut of one strain but not in another).
Our current data do not provide evidence that this is a biologically meaningful difference.
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