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Biologically, large inversions are more likely to be neutral, without obvious phenotypic consequences, compared to large CNVs.
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Jirsa, V.K. & Stefanescu, R.A. Neural population modes capture biologically realistic large scale network dynamics.
The source of these asymmetries and asynchronies is the very low numbers of copies of biologically important large molecules in each cell.
Firstly, TGF-β1 is synthesized as biologically inactive large latent complexes (LLCs) composed of a latent TGF-β binding protein (LTBP) covalently bound to the latency associated protein (LAP) and TGF-β.
Firstly, TGF-β1 is synthesized as biologically inactive large latent complexes composed of a latent TGF-β binding protein (LTBP) covalently bound to the latency associated protein (LAP) and TGF-β.
In particular, small reaction graphs can be recognized as motifs of biologically unrelated large reaction graphs.
Glycoproteins are biologically significant large molecules that participate in numerous cellular activities.
In order to reduce the arguably biologically implausibly large number of stages required by their first model, Armitage and Doll [ 105] developed a further model of carcinogenesis, which postulated a two-stage probabilistic process whereby a cell following an initial transformation into a pre-neoplastic state (initiation) was subject to a period of accelerated (exponential) growth.
However, MD, which makes no assumption about the underlying potential surfaces and allows transitions across energy barriers (which anharmonic motions include), is dearly needed to describe non-equilibrium dynamics involved in biologically important large conformational transitions, given a sufficient duration of simulations (Kitao et al. 1998; Arkhipov 2006a, b).
"... This paper studies neuromuscular mechanisms behind upright stance control by means of a biologically based large-scale neuromusculoskeletal (NMS) model.
In this paper we demonstrate an efficient, biologically realistic, large-scale SNN simulator that runs on a single GPU.
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