When initially synthesized within the cell, protein hormones are contained within large biologically inactive molecules called prohormones.
All of these hybrids are biologically inactive.
Etanercept is a dimeric fusion protein that binds specifically to TNF-α, rendering it biologically inactive.
hBLMH hydrolyzes BLMs into the biologically inactive deamido BLMs, thereby protecting organs from BLM-induced toxicity.
Hepatocyte growth factor (HGF) is biosynthesized as a biologically inactive, single-chain form (pro-HGF).
Prodrugs are biologically inactive agents that upon biotransformation in vivo result in active drug molecules.
IL-1β is produced in a biologically inactive form that requires protease-mediated cleavage to govern its proinflammatory functions.
The isomerization of ABA to the biologically inactive 2E-isomer by light considerably limits its applications in agricultural fields.
In 2015, we described the existence of biologically inactive leptin due to missense mutations (p.Asp100Tyr and p.Asn103Lys, see Fig. 1d) [7, 8].
For example, cases of biologically inactive protein have been reported for hormones like ACTH, TSH, as well as the leptin-related GH [33]-[36].
11β-Hydroxysteroid dehydrogenase (11β-HSD) enzymes catalyze the conversion of biologically inactive 11-ketosteroids into their active 11β-hydroxy derivatives and vice versa.
