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Fits that violated our biologically imposed constraints (positive A values and positive τ values) were discarded.
Superproteins are best defined as high-performance proteins that ignore at least some biologically imposed restrictions on amino acid sequence and occupy regions of sequence space unexplored by naturally occurring proteins optimized for in vivo function [5], [6].
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In other words, those aspects of humanity that are biologically inherited or socially imposed.
Therefore, additional biologically relevant constraints are imposed on fluxes of reactions in order to find substantive solutions of the system.
We impose biologically motivated structural constraints (corresponding to specific type of Boolean functions) and dynamical constraints (corresponding to stable attractor states) to limit the space of BN models for pancreas development.
We speculate that the highest concentration of indole (1 mM) used in this study is not biologically relevant, and imposes stress on the cell.
The constraint of a constant effect of DWT of more than 4 m (Eq. 8.51/Figure 3A) was imposed because it is biologically feasible that the effect of DWT is constant below a certain threshold.
A model that only accounts for mass balance is largely undefined and further constraints are imposed to enrich the range of feasible solutions with biologically realistic ones.
We used informatics approaches to impart biologically relevant information to the Xenopus inner ear transcriptome, thereby addressing the impediment imposed by insufficient gene annotation.
The dichotomy imposed by this approach may be artificially limiting these networks, causing biologically meaningful relationships to be overlooked (Carter et al. 2004).
Biologically feasible concentrations of internal metabolites and fixed concentrations of external metabolites, enzymes, transporters and inhibitors were imposed, then the ODE system integrated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com