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Indeed, our susceptibility to petty irritations may be biologically encoded.
It is almost certain that memory – a classic nurture problem: we learn something and it becomes biologically encoded – involves epigenetics.
It shifts into the biologically encoded survival mechanisms that are hardwired in that go with starvation mode," Albers tells me.
Thus, one can rely on the appearance of a consensus sequence as another indication that a given compound is a high quality hit, as has been seen many times in screens of biologically encoded libraries of peptides or aptamers.
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In conclusion, our method demonstrates that an enormous amount of biologically important information is encoded within genome scale patterns of codon usage, accessing this information does not require gene expression measurements, but instead carefully formulated biologically interpretable models.
Given the fact that one of the most important objectives of clustering analysis of SAGE data is to identify biologically-meaningful expression patterns encoded in the data, recent years have seen a growing trend towards the incorporation of prior biological knowledge to assess the quality of the clustering outcomes.
The genomes of vertebrates, those purported paragons of biological perfection, turned out to be veritable junkyards of selfish genetic elements where only a small fraction of the genetic material is dedicated to encoding biologically relevant information.
Another remarkable feature of the human airway basal cell signature is that it includes the genes encoding biologically active ligands and, in some cases, the corresponding receptors.
An association with DBP is biologically plausible: ENG encodes a type I membrane glycoprotein and is part of the TGF-beta receptor complex.
Genetic adjuvants are expression vectors encoding biologically active molecules such as cytokines, chemokines, soluble forms of cell ligands, adhesion proteins, or other immuno-reactive molecules [ 8].
Thus, it appears likely that, to the extent that they are functional, most of the uORFs are control elements, although a minority might encode biologically relevant peptides.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com