Biologically, disruption of CoRest/REST complex by ICP0 is of importance because the expression of a dominant negative CoREST protein in place of ICP0 results in improved replication of an ICP0 mutant virus (Gu & Roizman, 2007) and decreased replication of a virus mutant containing a lesion within the CoREST interaction region of ICP0 has been observed (Gu & Roizman, 2009).
LECTURE "Climate Disruption".
We reason that if PUs are biologically important, such disruptions should be avoided.
These results are biologically reasonable, as the disruption of coding regions of genes gives rise to different phenotypes.
It makes sense biologically.
"Primate eggs are biologically different".
As an independent method of assessing the potential biological implications of miRNA disruption, we performed pathway analysis on biologically validated targets of miRNAs (as annotated in miRTarBase v3.5) specifically deregulated in one smoking group.
Biologically, MDD is characterized by disruption of neurotransmitters, especially serotonin and noradrenaline, which are the main targets of antidepressants.
In other approaches, the intracellular components of the fungi are capable of producing biologically synthesized gold nanoparticles (BioAuNPs) after the disruption of the cells38,39.
A disease mechanism linked to disruption of SP-1 and ATF3-binding sites is biologically plausible, as nucleotide-binding factors linked to this site are associated with pancreatic injury responses, including inflammation and fibrosis.
In the scale-free molecular network, targeted disruption of limited numbers of critical components designated hubs, on which the biologically important molecular interactions concentrate, efficiently disturbs the whole cellular function by destabilizing the network [ 9].
