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Our approach leverages the platform p-value [11] and fold change cutoffs to designate whether changes in a gene constitute biologically differential expression between each treated sample relative to the vehicle-control pool.
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Accounting for biological variation in gene expression is important for reliable and biologically relevant differential expression analysis [ 65].
Furthermore, we also report genes with at least two-fold change, which may represent biologically meaningful differential expression levels.
Various components that constitute the system through developmental regulation are studied and connected by a system of biologically meaningful differential equations (DE).
Previous targeted testing of our samples identified several known regions of biologically significant differential methylation in addition to the cardinal disease loci.
To further evaluate the capability of RNA-Seq protocols to detect biologically relevant differential expression signals, we performed Significance Analysis of Microarray (SAM) on three Basal-like and three Luminal samples of UNC dataset that were sequenced by mRNA-seq, Ribo-Zero-Seq and DSN-Seq respectively.
Thus, the genome-based groupings have the potential to reveal biologically-interesting differential regulation of mRNA processing.
Overall, these results would suggest that our flax microarray platform is capable of detecting biologically-relevant differential gene expression between contrasted flax varieties.
We integrate a system of biologically meaningful delay differential equations (DDEs) into functional mapping, a statistical model designed to map dynamic QTLs involved in biological processes.
To further investigate biologically relevant targeting, differential miRNA and mRNA expression data was analyzed through the use of Ingenuity® microRNA target filter to generate lists of interactions between genes and miRNAs.
To investigate this, we have studied microgel deformation by translocation through cylindrical pores under biologically relevant pressure differentials in order to mimic renal filtration.
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