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Such considerations are likely to impact MoA research in that many such investigations are not justified, if at all, when toxicity is noted only under conditions of excessively high-dose testing that is not quantitatively relevant to human risk, e.g., test dose(s) above onset of nonlinear ADME behavior; in vitro test concentrations not biologically attainable in vivo.
This is impossible for many reasons, but mainly because not all the 2160 configurations of the regulators are biologically attainable.
For this reason, we do believe that the important quantity is the observed gene expression probability for the biologically attainable configurations.
However, these 152 experiments are absolutely relevant because they represent the observable and biologically attainable gene expression configurations of the organism.
Similar(56)
Not biologically.
It seemed attainable".
"It's attainable.
These are attainable things".
You're too attainable".
The impossible is attainable".
Perfection is attainable.
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