Since many of these generated signals far greater than 8-pCPT-cAMP, it was anticipated that biologically irrelevant hits would comprise a significant proportion of these.
It can be anticipated that new biologically defined and clinically relevant subtypes of leukaemia will be identified based on their unique gene expression profiles.
Based on the predictive pharmacokinetic/pharmacodynamic model, the biologically effective dose range was anticipated to be between 100 mg and 400 mg.
However, because of the randomization used during the blinded review, no correlation of the results was anticipated or deemed biologically plausible.
Since >70% of cytosines in the 5′-CpG-3′ sequence context are believed to be methylated in mammalian cells (3), the formation of Tg arising from oxidative damage to 5-methylcytosine is anticipated to be biologically significant.
The conservative predictions indeed anticipated a number of very promising, biologically interesting interactions.
These adverse events were not anticipated from preclinical studies with rodents; hence, more biologically relevant models, such as nonhuman primates, are needed to test the safety and efficacy of novel therapies for Alzheimer's disease.
Furthermore, we anticipated that breed-related gene expression profiles would uncover biologically and therapeutically significant pathways that would inform etiology and identify therapeutic targets.
Thus, its use can be reasonably anticipated to define relationships that are more likely to be biologically and clinically relevant.
In the 21st century, dramatic progress can be anticipated in early diagnoses and treatments of cancer, Alzheimer's, and other diseases, in the development of biologically inspired materials, devices, and energy sources, and in understanding how the human brain works.
