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Dramine sesquiterpenoids have been shown to possess extensive biologically activities, such as antifeedant, anti-inflammatory, cytotoxic, antioxidant and α-amylase inhibitory activities [21, 22, 23].
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The antimicrobial results suggested that Co-complex exhibits higher biologically activity against microbial tested strains in comparison to the ampicillin antibiotic.
For example, it was recognized that the gut microbiota-mediated metabolism of ginsenosides in ginseng may alter the pharmacokinetics of ginseng and enhance their biologically activity.
A phase I study in patients with advanced solid tumors using doses of oral vatalanib at 150 to 1,000 mg twice a day established that the maximum tolerated oral dose was 750 mg twice a day, whereas the biologically activity dose was more than 1,000 mg twice a day [ 119].
This is part of our effort to couple known moieties that offer antitumor activity with biologically active units hoping to increase the biological activity of the combination.
This study proposes the development of new compounds with dual biological activity, based on biologically active components: ethanolammonium as cation and 2-chloro-4-nitrobenzoate, 2-chloro-5-nitrobenzoate and respectively 4-nitrobenzoate as anions.
The -stereoisomer is biologically active and has activity on the ABA receptors, albeit substantially reduced.
Enzymatic bioreduction of nitro groups plays an important role on the activity of biologically active nitroaromatic compounds.
For this reason, many studies selected GBM 8401 cells as a model for human brain glioblastoma to analyze the antitumor activity of biologically active compounds.
Triterpene sapogenins are a group of biologically active compounds with antibacterial activity.
Reported literature about Colletotrichum species isolated from medicinal plants afforded an immunosuppressive novel peptide collutellin A along with wide range of biologically active natural metabolites including activity of cancer cell lines [84].
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