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Ketoconazole may be effective in maintaining biologically active levels of retinoic acid in epidermal cells.
Coupled with the efficiency of transfection, we have encountered difficulties measuring biologically active levels of IFN following transfection of vaginal epithelium.
Taken together, these results demonstrate that the transplantation of Nes-GFP+ cells can partially restore the disrupted LC function, leading to the production of biologically active levels of testosterone, which may improve spermatogenesis.
There is thus convincing evidence that biologically active levels of BPA in human blood are above the range that has been demonstrated to cause changes in function in human tissues based on in vitro studies.
Numerous studies have reported biologically active levels of phytoestrogens (particularly genistein, equol, and β-sitosterol) in effluent from wood pulp mills or sewage treatment plants or in agricultural soils [ 14– 16].
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Measurements in urine reflect metabolised amounts of hormones, but it is not clear how these levels relate to biologically active levels in breast tissue.
However, in the gastrointestinal tract, curcumin may attain biologically active levels.
Since our previous (Sidell et al, 2000) and present pharmacokinetic studies of RAG and 4-CPA indicated that biologically active blood levels of RAG, RA, and 4-CPA can be maintained during chronic long-term administration of the compounds, we assessed whether such levels could have therapeutic significance in terms of reduced in vivo tumour growth.
Biologically active, high levels of IL-22 do not affect obesity and the associated metabolic syndrome.
In summary, our findings suggest that biologically active, high levels of IL-22 do not affect obesity and its metabolic consequence.
Here, we provide evidence that endogenous IL-22 or biologically active, high circulating levels of IL-22 do not affect HFD-induced obesity and its metabolic consequences, although IL-22 is able to inhibit hepatic gluconeogenesis in hepatocytes.
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