Sentence examples for biologically active dose of from inspiring English sources

A biologically active dose of 1000 mg was identified in all three studies.

Centenera et al (2012) used ex vivo cultures to assess the biologically active dose of an Hsp90 inhibitor.

The primary objectives of this trial were to define the maximum tolerated dose (MTD), and to identify the optimal biologically active dose of MDX-H210.

However, the most well-tolerated biologically active dose of rhIL-7 that could be applied in phase IIb/III studies still remains unclear [ 16, 17] We report a phase I/IIa dose escalation study of repeated administration of a glycosylated rhIL-7 in HIV-1 infected HIV-1 infected CD4 T-cell counts failed to normalize despatientsologic suppression whoseantiretroviral (ARV) therapy.

The possibility is the intraarticular injection of biologically active doses of curcumin to metabolising chondrocytes and synoviocytes.

In this paper we summarize our efforts to apply measurements of DNA-protein cross-links (DPC) as test for biologically active doses of Cr VI).

Earlier studies have failed to demonstrate clearly the central involvement of cumulative energy intake of puberty because of the concomitant presence of biologically active doses of phytoestrogens in the foods (Odum et al. 2001; Thigpen et al. 2002, 2003).

The findings reported by Thigpen et al. (2003) that effects of DES could be masked by some batches of a commercial feed clearly demonstrate that, without an appropriate positive control, false-negative findings can occur that lead to the false conclusion that even biologically active doses of potent estrogenic drugs such as DES have no effect.

Nevertheless, for signal-searching phase I studies where biologically active doses of drugs are used in patients from the outset, it may be useful to use multiplexed targeted NGS platforms to investigate a range of 'hot-spot' mutations and other aberrations as putative predictive biomarkers of response and resistance.

In some instances, imaging results have helped to support the choice of a biologically active dose to be applied in later Phase II trials.

Some studies have also demonstrated a dose response relationship between the drug and Ktrans value, which has helped the selection of a biologically active dose for translation into the later phase clinical trials.