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Index Chemicus is a vital source of new information on biologically active compounds and natural products".--Publisher description.
Breast milk has always attracted research, traditionally as an invaluable nutritional source and recently as a medium containing various biologically active compounds and living cells14,15,16.
Paradoxically, analyses of the relationship between the selectivity of biologically active compounds and their molecular size suggest that promiscuous compounds should typically be smaller than target-selective compounds.
Amphibian skin secretions are considered a rich source of biologically active compounds and are known to be rich in peptides, bufadienolides and alkaloids.
Medicinal chemistry is considered as the scientific discipline concerned with the discovery, design, identification, and preparation of biologically active compounds and the interpretation of their mode of action at the molecular level and their metabolites.
Based on our hypothesis that the 3,3-diphenylpentane (DPP) skeleton is useful as a multi-template for creation of various biologically active compounds and acts as a steroid skeleton substitute, we designed and synthesized novel HMG-CoA reductase inhibitors with a DPP skeleton.
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With the breakthroughs in biomolecular engineering and synthetic biology, many valuable biologically active compound and commodity chemicals have been successfully manufactured using cell-based approaches in the past decade.
Sponge-associated actinobacteria have been reported to be prolific source of secondary metabolite producers [ 15, 16] and suggested to attribute largely to the chemical defense mechanisms of their host sponges against predators with biologically active compounds (repellents) and biofouling ([ 17] and references therein).
We and others have previously shown that airway and alveolar epithelial cells, including A549 cells, are activated by a variety of endogenous agents such as cytokines as well as exogenous stimuli including LPS and fine particles, and express biologically active compounds including cytokines and chemokines.
Meinwald's research has involved the isolation and identification of biologically active compounds from insect and other arthropod sources; pheromone systems of some amphibian and mammal species; and identification of messenger molecules involved in such systems and the understanding of underlying signal transduction pathways.
Carbacylamidophosphates as the structural analog of β-diketones, that are promising class of biologically active compounds with antimitotic and antiproliferative activities, can be used as antitumor agents [1 3].
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