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Biologically active complexes of genes and proteins, for example, small interfering RNA (siRNA), cytokines, enzymes, peptide hormones, and others, are the choice of drugs which could be very useful for the treatment of various diseases.
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Using GFP-binding proteins derived from Camelid antibodies, we co-opted GFP as a scaffold for inducing formation of biologically active complexes, developing a library of hybrid transcription factors that control gene expression only in the presence of GFP or its derivatives.
For example, the bacterial production of biologically active, complex multimeric proteins such as antibodies is limited by the absence of the enzymatic machinery involved in post-translational modification of newly-synthesised proteins [ 1, 2].
In this work, such alkylated imidazoles were synthesized and complexed with silver(I) by means of an eight/nine-step synthetic pathway we devised to access a new class of biologically active silver complexes.
Cobalamin, the biologically active form of vitamin B12, is an exquisitely complex natural product whose synthesis is limited to only some archaea and bacteria.
The two main biologically active forms of vitamin B12 (adenosylcobalamin and methylcobalamin) act as coenzymes and cofactors in complex rearrangement and methylation reactions, respectively [1].
Organic and Organometallic Chemistry — Total synthesis of biologically active and architecturally complex natural products as a platform for the development of new synthetic methods and strategies.
His research focuses on the total synthesis of biologically active and architecturally complex natural products as a platform for the development of new synthetic methods and strategies.
A new validated ACE inhibitors pharmacophore model (hypothesis) was generated for the first time in this research from the biologically active (frozen) conformation of Lisinopril–Human ACE complex that was downloaded from PDB, using stepwise technique of CATALYST modules.
This indicates that the mobility of the biologically active groups of PTX is highly constrained.
Aβ25-35 is the shortest biologically active fragment of full-length Aβ (1-42) that retains full toxicity31.
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