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In addition, biologically achievable dose and specificity of the drug should be determined further.
The biologic effects of KPT-335 were demonstrated when cells were treated with nanomolar concentrations of drug which have been shown to be biologically achievable in dogs following oral administration.
A similar drug screen for therapeutic compounds which improve prion disease outcomes unexpectedly identified the second generation selective histamine H1-receptor antagonist astmeizole as a potent inducer of autophagy at biologically achievable concentrations.
Similar(57)
The values of both N and s used in this work are well within biologically realistic ranges achievable in a microbiological laboratory.
These doses are biologically relevant and achievable based on pharmacokinetic data derived from studies in both healthy dogs and dogs enrolled in the phase 1 and 2 studies [ 33].
Obama achieved the achievable.
These biologically relevant concentrations are reported to be achievable in vivo [ 23, 26].
The achievable time-scales of computational simulations continue to slowly reach towards biologically relevant time-scales.
Like recent improvements in photon delivery, increased (biologically effective) doses in the tumor volume and/or reduced radiation dose in healthy organs - as achievable with protons according to theoretical planning studies - may further improve the therapeutic ratio of radiotherapy.
Not biologically.
Entirely achievable.
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