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We discovered several physical, chemical, and biological trends.
Gene ontology (GO) enrichment analysis of DEGs in the various contrasts was conducted to reveal biological trends differentiating tolerant and susceptible genotypes.
CBPLNs reveal high-level linkages between pathways and processes, making the identification of important biological trends more tractable than through interactions between individual genes and molecules alone.
Our approach is predicated on the belief that high-level linkages between pathways and processes make identification of important biological trends more tractable and intuitive than through interactions between individual genes and molecules alone.
Our analysis has identified both extreme codon usage patterns and biological trends in specific gene sets.
Furthermore, we utilized GenMAPP 2 [ 23] and Panther [ 24] to identify global biological trends in our gene expression data.
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This extension was considered particularly valuable when evaluating changes in CT values between 0.5 and 1.0 as shown here for β-actin where the biological trend in reference gene expression resulted in the erroneous gain or loss of statistical significance regarding genes of interest.
For example, deterministic gene regulatory models should be corroborated solely against the biological trend component; stochastic models will also include biological noise components.
While 1D expression data (spatial profiles) have been publicly available for more than a decade ("FlyEx" [ 54] and "BID BDTNP" [ 2, 19] Web resources), few publications have been devoted to decomposition of the data into biological trend and noise components.
Analyzing these, we find statistically significant enrichment for proteins involved in pathways related to cancer and type I diabetes mellitus, suggesting either a literature bias or a genuine biological trend.
We have also determined basic parameters that are useful for explanation of the biological activity trends and conducted docking of the compounds to homology-based SERT models [ 12].
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CEO of Professional Science Editing for Scientists @ prosciediting.com