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The development of a systematic approach to explore whether a given toxicological response does exhibit a biological threshold using a key events dose-response framework based on the mode of action responds to this concern.
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Biological impacts were assessed using a critical chemical threshold of 20 μeq l−1 for annual acid neutralising capacity (ANC).
Thus, 111 crystal-packing contacts, whose interface areas are larger than 127.4 Å (same values as the area threshold used in the biological contact set), were finally selected among the above 308 contacts and used in the following analyses.
To distinguish sequencing errors from true biological variation, we used a bit score threshold of 200 and only the best match for each sequence.
UCHIME reports a score for each sequence, allowing the user to trade sensitivity for specificity by adjusting the minimum score threshold used to discriminate chimeras from biological sequences.
However, since filter F2 uses a fold change threshold of 1.1--much smaller than the 1.5 threshold used in filter F1, we believe that only a subset of the 76 candidate proteins that changed at the subtle amount may have true biological significance.
As used in this project, a population threshold is an estimate of a biological threshold for a specified effect that holds for a specified proportion of a defined population.
Due to biological and experimental variability, a statistical threshold does not necessarily indicate the existence of a real biological threshold, nor does a real biological threshold necessarily lead to an observable statistical threshold.
To this end, we present a generalized approach for detecting potential ecological thresholds using assemblage-level attributes and a multimetric index (Index of Biological Integrity-IBI) as endpoints in response to numerical changes in water quality.
The biological-tumor-volume (BTV) was estimated by semiautomatic calculation of a VOI using a threshold of TBR ≥ 1.6, previously proposed as optimal threshold for differentiation of tumor and surrounding healthy tissue [23].
GSK Biologicals' 22F-inhibition ELISA was used to measure anti-pneumococcal serotype-specific total IgG concentrations using a threshold antibody concentration of 0.2 μg/ml, as described previously.
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