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Afterward, compounds were submitted for evaluation in biological testings after visual inspection of the hit list (Fig. 2).
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This will then enable the virtual 'crash-testing' of drugs before synthesis, biological testing and, most importantly, clinical trials.
In order to evaluate the drug-release behavior from pH-gradient liposomal formulation, a simple release-testing method without using biological components was newly designed on the basis of inversed ammonia gradient principle.
BUN and Cr testings were the most frequently overprescribed tests.
For IPA analysis, Fisher's exact test following a Benjamini and Hochberg correction for multiple-testing was used to estimate the significance of each biological function.
The program involves an effluent-testing program comprising a combination of chemical determination and biological activity monitoring (i.e., in vitro and in vivo assays).
Thus, these 11 CDS in our results could be biological false positives caused by the dependency model used in the multiple-testing correction, lowering their probability of being under the null hypothesis due to their conserved neighbors, which does not support the hypothesis of their HT.
BP: Examples of GO biological process over-represented in a module (with P < 0.05 after adjusting for multiple-testing).
In any case, hypothesis-testing procedures could be put on a better footing if decisions about a biological or toxicologic effect size of relevance would form the starting point of power analyses.
This network approach provides a hypothesis-testing framework for explaining similarities between any two or more small molecules based on the biological processes to which they are connected in the network.
Table 4 offers a more detailed description of these associations, including examples of GO biological process over-represented in the target module (statistically detectable at P < 0.05, after adjusting for multiple-testing).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com