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Preliminary biological study of these compounds provided potent compounds d21 and d22 with better activities than Rucaparib.
Preliminary biological study of these compounds provided potent compounds 17a, 33b, 33c, 33d, and 33g with low nanomolar IC50s against PARP-1 enzyme.
Details of the isolation, structure elucidation and biological study of these secondary metabolites are reported herein.
Unfortunately, the biological study of these two genes is not sufficient to address their putative roles in reproduction.
Our phylogenetic results are valuable not only for encouraging new systematic and taxonomic work on the group, but also for providing a framework for the comparative biological study of these specialized predators.
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Dr. Cowles authored several works on marine life including A Biological Study of the Offshore Waters of the Chesapeake Bay (1930) and wrote articles for the JHU Naturalists Clubb.
Previous phytochemical investigations and biological study of the plant were limited.
In this work, we also present the first results of biological studies of these two compounds.
Finally, based on biochemical and biological studies of these constructs expressed in mouse (C2C12) or Human HEKK) cells, we aim to confirm the functional modularity of dysferlin.
To investigate the mechanistic aspects underlying the activity, the detailed biological studies of these promising conjugates (5d and 5u) were carried out on the MDA MB-231 cancer cells.
Molecular and biological studies of these transgenic plants allow a better understanding of signaling pathways, cross talks, and pathogen specificities.
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