Sentence examples for biological screen from inspiring English sources
Such macrocycle collections should contain compounds with a broad range of biological activities (including antibacterial activities) and the requisite robust synthetic methodology useful for analogue synthesis and lead optimization once an active compound has been identified in a biological screen.
Even though such vast collections only constitute a small fraction of possible chemical space, it is still very difficult to apply a typical biological screen to all molecules in a collection when seeking novel hits on targets of interest [11].
It was next determined if transduced human cells expressing the unique surface anchored scFvFc could be used directly in a biological screen.
Our results show the utility of combining focused small molecule derivation, applied to a biological screen using the zebrafish model, to identify new compounds with desired target activity and specificity.
It is interesting to note that our biological screen also revealed the Dicer gene, albeit in an unexpected manner.
A candidate gene identified in any biological screen can be searched for a putative role in aberrant CpG methylation.
Microfluidic Methods for High-Throughput Biological Screening.
The valuable ones were protruded by biological screening.
Drugs are developed from the optimization of 'lead' molecules, which are frequently found through the biological screening of compound collections.
One of the hits (AW01208), with good predictions was selected for synthesis and biological screening.
Thereafter, the biological screening was done through cytotoxicity, anti-invasion and apoptosis-related assays.
