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In what some are calling the "biorights" movement, patients are refusing to provide specimens unless they are compensated; are promised that useful medical information will be returned to them; or are granted some control over how their biological samples will be studied.
MRI copies and biological samples will be archived.
Biological samples will be biobanked for future studies.
Furthermore, researchers who collect biological samples will be blinded to the allocation of women's group.
No additional biological samples will be kept for use in ancillary studies.
All provided biological samples will be labelled with a re-identifiable study number.
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In order to evaluate the intraindividual variability of biomarkers of early effect, a third environmental and biological sampling will be carried out in the following winter, restricted to 200 children recruited in Brescia.
If the treatment effect is weak compared to the technical and biological variation the samples will be difficult to discriminate based on the data.
Biological and air samples will be repeated in winter and spring, seasons characterised by different type and concentration of air pollutants.
The estimation error decreases with the number of no-variation genes detected (Fig. 2), and whenever normalization error is well below biological variation, normalization between samples will be correct and beneficial for downstream analyses.
In France, studies involving biological sampling require details on how samples will be used and stored, as well as information about future studies and whether genetic analysis will be conducted.
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